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Thu, Feb. 28th, 2008, 04:14 am


Depression drugs 'little better than placebos': study

By Katherine Haddon AFP - Tuesday, February 26 04:51 pm

LONDON, Feb 26, 2008 (AFP) - Best-s elling anti-depressants like Prozac and Seroxat are barely more effective than placebos in treating most people with depression, a study led by a British university said Tuesday.

The research, which analysed 47 clinical trials, breaks new ground by incorporating data not previously released by drug companies which researchers obtained under US freedom of information laws.

Its findings prompted some academics and mental health campaigners to question whether people with mild and moderate depression should be prescribed drugs like Prozac, which has been taken by 40 million people worldwide.

"The difference in improvement between patients taking placebos and patients taking anti-depressants is not very great," said Professor Irving Kirsch of Hull University, in northern England, who led the team.

"This means that depressed people can improve without chemical treatments.

"Given these results, there seems little reason to prescribe antidepressant medication to any but the most severely depressed patients unless alternative treatments have failed to provide a benefit."

The study, published in the journal PLoS (Public Library of Science) Medicine, looked at Prozac, Seroxat, Effexor and Serzone and found the drugs were only better than a placebo for some people with severe depression.

Kirsch's team said it was one of the most thorough probes into the impact of new generation anti-depressants or selective serotonin reuptake inhibitors (SSRIs).

But drug companies strongly questioned the findings.

A spokesman for Eli Lilly, which makes Prozac, said that "extensive scientific and medical experience" had shown it is "an effective anti-depressant."

And GlaxoSmithKline, which makes Seroxat, said the study had not acknowledged the "very positive benefits" of the drugs.

"Their conclusions are at odds with what has been seen in actual clinical practice," a spokesman said.

"It is widely recognised by experts in the field that studies in depression are challenging and very difficult to conduct."

One leading academic who has studied why drug companies only publish some of their data on new drugs said in the wake of the findings they should be obliged to provide full details.

Doctor Tim Kendall, deputy director of Britain's Royal College of Psychiatrists research unit, said the study was "fantastically important."

"I think it's too dangerous to allow drug companies -- where profit is a key factor -- to be able to withhold data which shows that a drug is ineffective or harmful," he said.

Alison Cobb, of British mental health charity Mind, hailed the findings as "a serious challenge to the predominance of drugs in treating depression."

"Anti-depressants do help many people but by no means all and some people experience severe side-effects with them," she said.

"Nine out of 10 GPs (general practitioners) say they've been forced to dish out drugs because they don't have proper access to 'talking treatments' such as cognitive behavioural therapy, which are recommended as the first-line treatment for mild to moderate depression."

Another mental health charity, Sane, warned the findings "could remove what has been seen as a vital choice for thousands," adding people should not stop taking their drugs immediately.

As the study was published, the British government published details of a 170-million-pound (225-million-euro, 335-million dollar) programme to improve access to counselling and therapy for people with depression.

Officials say this should see 900,000 more people receiving such treatments over the next three years.

Thu, Feb. 28th, 2008 09:16 am (UTC)

And there goes my paranoia level. I swear to TPTB they will do ANYTHING to get people out of NHS care. Take the depressed off meds by all means...there might be a few fatalities but, hey, they won't be the NHS's problem anymore then will they?

Nice of them to put that little side note in about people shouldn't stop taking their drugs immediately (get that idea to stop them in peoples heads though)...I suppose it would have been too much to mention the side-effects of suddenly stopping meds...you know, convulsions, heart palpitations, death.

You have to wonder if they will be taking sick people out behind the barn and shooting them next? I suppose they would grudge the funds for bullets though.

Sat, Apr. 5th, 2008 07:24 pm (UTC)

My God. Are these people MORONS!? Yes, you can HELP the treatment of depression by positive thinking and state of mind, so we have counseling for that, but the drugs are necessary!

I personally needed the help of drugs to get me INTO a place where I could face up to counseling!

These people make me sick! I agree with mrs_ralph, they just wanna save money!